Endocrine Abstracts

TSH receptor (TSHR) is a G-protein-coupled seven-transmembrane domain receptor located in the basolateral membrane of thyroid follicular cells. The activated receptor couples to two major signal transductions pathways: the Gs/adenylate cyclase and the Gq/11/phospholipase C signalling. Many loss of function mutations have been identified in this gene leading to a wide spectrum of thyroid abnormalities, ranging from hyperthyrotropinemia and TSH resistance to severe hypothyroidis...

Background: Variations in gut microbiota might impact metabolic functions like caloric intake and energy expenditure leading to body weight excess. Microbiota modulation may be a potential approach for obesity management, especially in subject characterized by specific microbial enterotypes.Objective: We aimed to assess the impact of probiotic treatment in obese children and adolescents, under diet control, on weight loss, glucose, and insulin homeostasi...